concept

BLOOD-BRAIN BARRIER INTEGRITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLOOD-BRAIN BARRIER INTEGRITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

2Analyses

2Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	BLOOD-BRAIN BARRIER INTEGRITY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    BLOOD_BRAIN_BARRIER_INTEGRITY["BLOOD-BRAIN BARRIER INTEGRITY"]
    CLDN5["CLDN5"] -->|"component_of"| BLOOD_BRAIN_BARRIER_INTEGRITY
    A1_Astrocytes["A1 Astrocytes"] -->|"downregulates"| BLOOD_BRAIN_BARRIER_INTEGRITY
    Dolutegravir["Dolutegravir"] -->|"inhibits"| BLOOD_BRAIN_BARRIER_INTEGRITY
    A1_Reactive_Astrocytes["A1 Reactive Astrocytes"] -->|"downregulates"| BLOOD_BRAIN_BARRIER_INTEGRITY
    Adherens_Junction_Components["Adherens Junction Components"] -->|"regulates"| BLOOD_BRAIN_BARRIER_INTEGRITY
    CX43["CX43"] -->|"involved_in"| BLOOD_BRAIN_BARRIER_INTEGRITY
    Butyrate["Butyrate"] -.protects against.-> BLOOD_BRAIN_BARRIER_INTEGRITY

Outgoing (2)

Target	Relation	Type	Str
cognitive decline	protects_against	phenotype	0.85
Cerebral Small Vessel Disease	involved_in	disease	0.73

Incoming (64)

Source	Relation	Type	Str
CLDN5	component_of	protein	0.95
Deubiquitinating Enzymes	regulates	enzyme	0.95
CLDN5	regulates	protein	0.95
Dolutegravir	associated_with	drug	0.90
CLDN5	involved_in	protein	0.90
A1 Astrocytes	downregulates	phenotype	0.90
Dolutegravir	inhibits	drug	0.90
A1 Reactive Astrocytes	downregulates	phenotype	0.90
Adherens Junction Components	regulates	protein	0.90
TDP-43	associated_with	protein	0.90
DTG	associated_with	drug	0.90
CXCR7	regulates	receptor	0.88
CX43	involved_in	gene	0.88
Indoxyl Sulfate	associated_with	compound	0.85
Butyrate	protects_against	compound	0.85
Acetate	protects_against	compound	0.85
Propionate	protects_against	compound	0.85
Paracellular Permeability	associated_with	phenotype	0.85
PI3K/AKT Pathway	regulates	pathway	0.85
Ams-17	associated_with	compound	0.85
ANXA1	associated_with	protein	0.85
ANXA2	associated_with	protein	0.85
ANXA1	involved_in	protein	0.85
FGFR1-SIRT1	regulates	pathway	0.85
ANXA1	modulates	protein	0.85
ANXA2	modulates	protein	0.85
MMP9	associated_with	protein	0.85
pericytes	associated_with	cell_type	0.85
deubiquitinating enzymes	regulates	protein	0.85
SASP factors	associated_with	protein	0.85
LRP1	biomarker_for	gene	0.85
lipid metabolism dysregulation	associated_with	process	0.85
endothelial dysfunction	associated_with	phenotype	0.85
Autophagy	protects_against	process	0.85
Dysbiosis	associated_with	phenotype	0.85
mitochondrial dysfunction	associated_with	process	0.85
PI3K/AKT	regulates	pathway	0.85
ANXA1	regulates	protein	0.80
APOE4	downregulates	protein	0.80
NRF2	involved_in	protein	0.80
CTNNB1	associated_with	protein	0.80
ANXA2	regulates	protein	0.80
ZO-1	involved_in	protein	0.80
Border-Associated Macrophages	regulates	cell_type	0.80
Short-Chain Fatty Acids	protects_against	compound	0.80
UCHL1	associated_with	gene	0.80
CLDN5	mediates	gene	0.80
time-restricted feeding	associated_with	process	0.80
APOE	regulates	gene	0.80
Crocetin	associated_with	compound	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why do TAM receptors protect against neuroinvasive viruses despite their known i

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.499

Why do TAM receptors protect against neuroinvasive viruses despite their known i

neuroinflammation | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BLOOD-BRAIN BARRIER INTEGRITY

Understanding Entity Pages

Wiki Pages (20)

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